•Clone the DNA.
•Generate a ladder of labeled (colored) molecules that are different by 1 nucleotide.
•Separate mixture on some matrix.
•Detect fluorochrome by laser.
•Interpret peaks as string of DNA.
•Strings are 500 to 1,000 letters long
•1 machine generates 57,000 nucleotides/run
•Assemble all strings into a “whole”. 
Picture 22.png
Basics of the “Old” Technology