•It is the geometric mean of all the enrichment P-values (EASE scores) for each annotation term associated with the gene members in the group. •To emphasize that the geometric mean is a relative score instead of an absolute P-value, minus log transformation is applied on the average P-values. •A higher score for a group indicates that the gene members in the group are involved in more important (enriched) terms in a given study; therefore, more attention should go to them