A single Nimblgen 2.1M array
is capable of
enrichment simultaneously more than 180,000 human coding-exon and 550 miRNA exons available in the CCDS database.
The methods significantly improve the efficiency, the cost and throughput of target enrichment compared to conventional PCR-based methods.
The human exome captured library preparation consists of three major processes and lasts seven days, including library preparation for sequence capture, microarray hybridization, elution and library construction for sequencing, using Illumina Genome Analyzer can directly get high quality sequence data for the entire human exome.
This approach can find the exact genes and mutations causing several complex human diseases, such as cancer, diabetes, obesity and so on.
Human Exome
Sequencing