•Typical sizing is 2GB of RAM per core
•This works fine for most aligners
–Certain aligners require a minimum number of cores for optimal efficiency
–16-48GB RAM per node
•Assemblers typically need much more RAM
•If you don’t have enough RAM, the CPU will need to make use of the disk storage –
•When a computer has run out of RAM it is said to be “swapping”
•Some aligners have a minimum memory limit for optimal performance
•Human de novo requires lots of RAM!