RPS-BLAST 2.2.4 [Aug-26-2002]
Query= local sequence:
(925 letters)
Database: oasis_sap.v1.58
4540 PSSMs; 885,521 total columns
 .. This CD
alignment includes 3D structure. To display structure, download Cn3D!
| |
PSSMs producing
significant alignments: |
Score
(bits) |
E
value |
| |
|
gnl|CDD|7317 |
smart00192, LDLa, Low-density lipoprotein
receptor domain clas... |
49.5 |
5e-07 |
|
gnl|CDD|7317 |
smart00192, LDLa, Low-density lipoprotein
receptor domain clas... |
46.8 |
3e-06 |
|
gnl|CDD|7317 |
smart00192, LDLa, Low-density lipoprotein
receptor domain clas... |
41.4 |
1e-04 |
|
gnl|CDD|120 |
smart00135, LY, Low-density
lipoprotein-receptor YWTD domain; ... |
47.1 |
3e-06 |
|
gnl|CDD|120 |
smart00135, LY, Low-density
lipoprotein-receptor YWTD domain; ... |
43.3 |
4e-05 |
|
gnl|CDD|7432 |
pfam00058, ldl_recept_b, Low-density
lipoprotein receptor repe... |
45.9 |
6e-06 |
|
gnl|CDD|7431 |
pfam00057, ldl_recept_a, Low-density
lipoprotein receptor doma... |
46.1 |
6e-06 |
|
gnl|CDD|7431 |
pfam00057, ldl_recept_a, Low-density
lipoprotein receptor doma... |
44.5 |
1e-05 |
|
gnl|CDD|7431 |
pfam00057, ldl_recept_a, Low-density
lipoprotein receptor doma... |
39.9 |
4e-04 |
|
gnl|CDD|7317, smart00192, LDLa, Low-density
lipoprotein receptor domain class A; Cysteine-rich repeat in the
low-density lipoprotein (LDL) receptor that plays a central role in
mammalian cholesterol metabolism. The N-terminal type A repeats in
LDL receptor bind the lipoproteins. Other homologous domains occur
in related receptors, including the very low-density lipoprotein
receptor and the LDL receptor-related protein/alpha 2-macroglobulin
receptor, and in proteins which are functionally unrelated, such as
the C9 component of complement. Mutations in the LDL receptor gene
cause familial hypercholesterolemia. | CD-Length = 38 residues, 97.4% aligned
Score = 49.5 bits (118), Expect = 5e-07
Query: 75 CSTSFMLCKNGLCVANEFKCDGEDDCRDGSDEQHCEY 111
Sbjct: 2 CPPGEFQCKNGRCIPLSWVCDGVDDCGDGSDEENCPS 38
|
gnl|CDD|7317, smart00192, LDLa, Low-density
lipoprotein receptor domain class A; Cysteine-rich repeat in the
low-density lipoprotein (LDL) receptor that plays a central role in
mammalian cholesterol metabolism. The N-terminal type A repeats in
LDL receptor bind the lipoproteins. Other homologous domains occur
in related receptors, including the very low-density lipoprotein
receptor and the LDL receptor-related protein/alpha 2-macroglobulin
receptor, and in proteins which are functionally unrelated, such as
the C9 component of complement. Mutations in the LDL receptor gene
cause familial hypercholesterolemia. | CD-Length = 38 residues, 100.0% aligned
Score = 46.8 bits (111), Expect = 3e-06
Query: 136 ECHPPRLRCRSGQCIQPDLVCDGHQDCSGGDDEVNCTR 173
Sbjct: 1 TCPPGEFQCKNGRCIPLSWVCDGVDDCGDGSDEENCPS 38
|
gnl|CDD|7317, smart00192, LDLa, Low-density
lipoprotein receptor domain class A; Cysteine-rich repeat in the
low-density lipoprotein (LDL) receptor that plays a central role in
mammalian cholesterol metabolism. The N-terminal type A repeats in
LDL receptor bind the lipoproteins. Other homologous domains occur
in related receptors, including the very low-density lipoprotein
receptor and the LDL receptor-related protein/alpha 2-macroglobulin
receptor, and in proteins which are functionally unrelated, such as
the C9 component of complement. Mutations in the LDL receptor gene
cause familial hypercholesterolemia. | CD-Length = 38 residues, 86.8% aligned
Score = 41.4 bits (97), Expect = 1e-04
Query: 37 EFDCGNGRLRCIPAEWQCDNVADCDKGRDESGCSY 71
Sbjct: 6 EFQCKNGR--CIPLSWVCDGVDDCGDGSDEENCPS 38
|
gnl|CDD|120, smart00135, LY, Low-density
lipoprotein-receptor YWTD domain; Type "B" repeats in low-density
lipoprotein (LDL) receptor that plays a central role in mammalian
cholesterol metabolism. Also present in a variety of molecules
similar to gp300/megalin. | CD-Length = 43 residues, 100.0% aligned
Score = 47.1 bits (112), Expect = 3e-06
Query: 552 RILLDNKLEVPSALAIDYIRHDVYFGDVERQLIERVNIDTKER 594
Sbjct: 1 RVLLSEGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
|
gnl|CDD|120, smart00135, LY, Low-density
lipoprotein-receptor YWTD domain; Type "B" repeats in low-density
lipoprotein (LDL) receptor that plays a central role in mammalian
cholesterol metabolism. Also present in a variety of molecules
similar to gp300/megalin. | CD-Length = 43 residues, 97.7% aligned
Score = 43.3 bits (102), Expect = 4e-05
Query: 595 RVVISNGVHHPYDMA--YFNGFLYWADWGSESLKVQEMTHHH 634
Sbjct: 1 RVLLSEGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
|
gnl|CDD|7432, pfam00058, ldl_recept_b, Low-density
lipoprotein receptor repeat class B. This domain is also known as
the YWTD motif after the most conserved region of the repeat. The
YWTD repeat is found in multiple tandem repeats and has been
predicted to form a beta-propeller structure. | CD-Length = 43 residues, 100.0% aligned
Score = 45.9 bits (109), Expect = 6e-06
Query: 527 GLIIWIDSYQKYHRIMMANMDGSQVRILLDNKLEVPSALAIDYI 570
Sbjct: 1 GRLYWTDSSLR-ASISVADLNGSDRRTLFSEDLQHPNGIAVDWI 43
|
gnl|CDD|7431, pfam00057, ldl_recept_a, Low-density
lipoprotein receptor domain class A. | CD-Length = 39 residues, 94.9% aligned
Score = 46.1 bits (109), Expect = 6e-06
Query: 135 PECHPPRLRCRSGQCIQPDLVCDGHQDCSGGDDEVNC 171
Sbjct: 1 STCGPNEFQCGSGECIPMSWVCDGDPDCEDGSDEKNC 37
|
gnl|CDD|7431, pfam00057, ldl_recept_a, Low-density
lipoprotein receptor domain class A. | CD-Length = 39 residues, 89.7% aligned
Score = 44.5 bits (105), Expect = 1e-05
Query: 75 CSTSFMLCKNGLCVANEFKCDGEDDCRDGSDEQHC 109
Sbjct: 3 CGPNEFQCGSGECIPMSWVCDGDPDCEDGSDEKNC 37
|
gnl|CDD|7431, pfam00057, ldl_recept_a, Low-density
lipoprotein receptor domain class A. | CD-Length = 39 residues, 97.4% aligned
Score = 39.9 bits (93), Expect = 4e-04
Query: 30 STCDQAKEFDCGNGRLRCIPAEWQCDNVADCDKGRDESGCS 70
Sbjct: 1 STC-GPNEFQCGSGE--CIPMSWVCDGDPDCEDGSDEKNCA 38
|
