BLAST Search Results

BLAST Search Results
Page 1 of 2
BLASTP 2.0.8 [Jan-05-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query = npm_human.sw
         (294 letters)

Database: swplus
           257,043 sequences; 82,848,034 total letters

Sequence	Description	Score (Bits)	E Value
SW:NPM_HUMAN alignment	P06748 homo sapiens (human). nucleophosmin (npm) (... 486 e-137	486	e-137
SW:NPM_RAT alignment	P13084 rattus norvegicus (rat). nucleophosmin (npm) ... 467 e-131	467	e-131
SW:NPM_MOUSE alignment	Q61937 mus musculus (mouse). nucleophosmin (npm) (... 467 e-131	467	e-131
SW:NPM_CHICK alignment	P16039 gallus gallus (chicken). nucleophosmin (npm...	330	4e-90
SW:NPM_XENLA alignment	P07222 xenopus laevis (african clawed frog). nucle...	300	6e-81
SP_OV:Q91802 alignment	Q91802 xenopus laevis (african clawed frog). no38....	300	8e-81
SP_OV:O42584 alignment	O42584 xenopus laevis (african clawed frog). nova....	106	1e-22
SW:NUPL_XENLA alignment	P05221 xenopus laevis (african clawed frog). nucl...	105	2e-22
SP_HUM:O75607 alignment	O75607 homo sapiens (human). nucleoplasmin-3. 11/...	96	2e-19
SP_IN:P91753 alignment	P91753 lytechinus pictus (painted sea urchin). mit...	62	3e-09
SP_IN:Q94555 alignment	Q94555 drosophila virilis (fruit fly). histone h1....	38	0.047
SP_IN:Q17362 alignment	Q17362 caenorhabditis elegans. unc-89. 11/1998	37	0.14
SP_IN:O01761 alignment	O01761 caenorhabditis elegans. c. elegans unc-89 (...	37	0.14
SP_IN:Q94972 alignment	Q94972 drosophila virilis (fruit fly). histone h1....	36	0.18
SW:NFH_RAT alignment	P16884 rattus norvegicus (rat). neurofilament triple...	36	0.24
SW:H1_DROVI alignment	Q24704 drosophila virilis (fruit fly). histone h1. ...	36	0.31
SP_IN:Q27415 alignment	Q27415 drosophila melanogaster (fruit fly). crp1 p...	36	0.31
SP_PL:O65794 alignment	O65794 triticum aestivum (wheat). histone h1. 11/1998	35	0.41
SP_OM:O77788 alignment	O77788 bos taurus (bovine). neurofilament-m subuni...	35	0.41
SW:H1B_HUMAN alignment	P10412 homo sapiens (human). histone h1b (h1.4). 6...	35	0.54
SP_IN:O17965 alignment	O17965 caenorhabditis elegans. m01e5.5b protein. 8...	35	0.54
SW:H12_RAT alignment	P15865 rattus norvegicus (rat). histone h1.2 (h1d). ...	34	0.70
SP_HUM:Q13061 alignment	Q13061 homo sapiens (human). triadin. 8/1998	34	0.70
SP_HUM:Q14529 alignment	Q14529 homo sapiens (human). histone h1.5. 11/1998	34	0.70
SW:ENL_HUMAN alignment	Q03111 homo sapiens (human). enl protein. 10/1996	34	0.92
SP_HUM:Q14768 alignment	Q14768 homo sapiens (human). enl protein. 1/1999	34	0.92
SP_RO:O35482 alignment	O35482 rattus norvegicus (rat). high molecular-wei...	34	0.92
SP_IN:O61215 alignment	O61215 caenorhabditis elegans. w01b11.1 protein. 1...	33	1.6
SP_OM:Q28688 alignment	Q28688 oryctolagus cuniculus (rabbit). neurofilame...	33	1.6
SP_OM:Q28687 alignment	Q28687 oryctolagus cuniculus (rabbit). neurofilame...	33	1.6
SP_IN:O18642 alignment	O18642 chaetopterus variopedatus. histone h1. 11/1998	33	2.1
SP_IN:O61214 alignment	O61214 caenorhabditis elegans. w03d8.3 protein. 11...	33	2.1
SP_IN:Q23903 alignment	Q23903 dictyostelium discoideum (slime mold). 5'-b...	33	2.1
SW:H10_HUMAN alignment	P07305 homo sapiens (human). histone h1' (h1.0) (h...	32	2.7
SW:H1L_MYTTR alignment	Q05831 mytilus trossulus (blue mussel). sperm-spec...	32	2.7
SP_FUN:O42854 alignment	O42854 schizosaccharomyces pombe (fission yeast)....	32	2.7
SP_IN:P91122 alignment	P91122 caenorhabditis elegans. similarity human to...	32	2.7
SP_PL:Q41111 alignment	Q41111 phaseolus vulgaris (kidney bean) (french be...	32	2.7
SW:3F_DICDI alignment	P13475 dictyostelium discoideum (slime mold). 3f pr...	32	3.6
SW:H14_MOUSE alignment	P43274 mus musculus (mouse). histone h1.4 (h1 var....	32	3.6
SP_IN:Q23330 alignment	Q23330 caenorhabditis elegans. coded for by c. ele...	32	3.6
SP_IN:O45198 alignment	O45198 caenorhabditis elegans. w09g12.7 protein. 1...	32	3.6
SP_RO:Q62485 alignment	Q62485 mus musculus (mouse). cochlear mrna (clone ...	32	3.6
SP_RO:O55035 alignment	O55035 rattus norvegicus (rat). matrin cyclophilin...	32	3.6
SP_IN:P91959 alignment	P91959 psammechinus miliaris (sand sea urchin). cl...	32	4.7
SP_IN:Q21351 alignment	Q21351 caenorhabditis elegans. k08f4.2 protein. 1/...	32	4.7
SP_PL:O49596 alignment	O49596 arabidopsis thaliana (mouse-ear cress). hmg...	32	4.7
SP_OV:Q91369 alignment	Q91369 xenopus laevis (african clawed frog). h1a=s...	32	4.7
SW:YQ58_CAEEL alignment	Q09464 caenorhabditis elegans. hypothetical 28.5 ...	31	6.1
SP_RO:P27734 alignment	P27734 rattus norvegicus (rat). calcium channel al...	31	6.1


Run Parameters
  Database: swplus
    Posted date:  Mar 27, 1999  9:20 AM
  Number of letters in database: 82,848,034
  Number of sequences in database:  257,043
  
Lambda     K      H
   0.310    0.129    0.365 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42388027
Number of Sequences: 257043
Number of extensions: 1576032
Number of successful extensions: 5432
Number of sequences better than 10.0: 59
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 5237
Number of HSP's gapped (non-prelim): 182
length of query: 294
length of database: 82848034
effective HSP length: 58
effective length of query: 236
effective length of database: 67939540
effective search space: 16033731440
effective search space used: 16033731440
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.8 bits)
S2: 68 (30.9 bits)

Input Sequence: npm_human.sw

!!AA_SEQUENCE 1.0
ID   NPM_HUMAN      STANDARD;      PRT;   294 AA.
AC   P06748; P08693; Q12826; Q14115; Q13440; Q13441;
DT   01-JAN-1988 (REL. 06, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   NUCLEOPHOSMIN (NPM) (NUCLEOLAR PHOSPHOPROTEIN B23) (NUMATRIN)
DE   (NUCLEOLAR PROTEIN NO38).
GN   NPM1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89229105.
RA   CHAN W.Y., LIU Q.R., BORJIGIN J., BUSCH H., RENNERT O.M., TEASE L.A.,
RA   CHAN P.-K.;
RT   "Characterization of the cDNA encoding human nucleophosmin and
RT   studies of its role in normal and abnormal growth.";
RL   BIOCHEMISTRY 28:1033-1039(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89374300.
RA   LI X., MCNEILAGE L.J., WHITTINGHAM S.;
RT   "The nucleotide sequence of a human cDNA encoding the highly
RT   conserved nucleolar phosphoprotein B23.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 163:72-78(1989).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 90026373.
RA   ZHANG X.T., THOMIS D.C., SAMUEL C.E.;
RT   "Isolation and characterization of a molecular cDNA clone of a human
RT   mRNA from interferon-treated cells encoding nucleolar protein B23,
RT   numatrin.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 164:176-184(1989).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 97248692.
RA   CHAN P.K., CHAN F.Y., MORRIS S.W., XIE Z.;
RT   "Isolation and characterization of the human nucleophosmin/B23 (NPM)
RT   gene: identification of the YY1 binding site at the 5' enhancer
RT   region.";
RL   NUCLEIC ACIDS RES. 25:1225-1232(1997).
RN   [5]
RP   SEQUENCE OF 15-294 FROM N.A. (CLONE HL6T).
RX   MEDLINE; 90098787.
RA   HALE T.K., MANSFIELD B.C.;
RT   "Nucleotide sequence of a cDNA clone representing a third allele of
RT   human protein B23.";
RL   NUCLEIC ACIDS RES. 17:10112-10112(1989).
RN   [6]
RP   SEQUENCE OF 213-294 FROM N.A.
RX   MEDLINE; 87033628.
RA   CHAN P.-K., CHAN W.-Y., YUNG B.Y.M., COOK R.G., ALDRICH M.B.,
RA   KU D., GOLDKNOPF I.L., BUSCH H.;
RT   "Amino acid sequence of a specific antigenic peptide of protein B23.";
RL   J. BIOL. CHEM. 261:14335-14341(1986).
RN   [7]
RP   SEQUENCE OF 1-117 FROM N.A.
RC   TISSUE=LYMPHOMA;
RX   MEDLINE; 94167588.
RA   MORRIS S.W., KIRSTEIN M.N., VALENTINE M.B., DITTMER K.G.,
RA   SHAPIRO D.N., SALTMAN D.L., LOOK A.T.;
RT   "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in
RT   non-Hodgkin's lymphoma.";
RL   SCIENCE 263:1281-1284(1994).
RN   [8]
RP   SEQUENCE OF 1-117 FROM N.A.
RX   MEDLINE; 96210614.
RA   FUJIMOTO J., SHIOTA M., IWAHARA T., SEKI N., SATOH H., MORI S.,
RA   YAMAMOTO T.;
RT   "Characterization of the transforming activity of p80, a
RT   hyperphosphorylated protein in a Ki-1 lymphoma cell line with
RT   chromosomal translocation t(2;5).";
RL   PROC. NATL. ACAD. SCI. U.S.A. 93:4181-4186(1996).
RN   [9]
RP   SEQUENCE OF 1-133 FROM N.A.
RC   TISSUE=BONE MARROW;
RX   MEDLINE; 96151966.
RA   REDNER R.L., RUSH E.A., FAAS S., RUDERT W.A., COREY S.J.;
RT   "The t(5;17) variant of acute promyelocytic leukemia expresses a
RT   nucleophosmin-retinoic acid receptor fusion.";
RL   BLOOD 87:882-886(1996).
RN   [10]
RP   SEQUENCE OF 115-134.
RX   MEDLINE; 86111864.
RA   CHAN P.-K., ALDRICH M.B., COOK R.G., BUSCH H.;
RT   "Amino acid sequence of protein B23 phosphorylation site.";
RL   J. BIOL. CHEM. 261:1868-1872(1986).
RN   [11]
RP   SEQUENCE OF 33-54.
RC   TISSUE=COLON CARCINOMA;
RX   MEDLINE; 97295306.
RA   JI H., REID G.E., MORITZ R.L., EDDES J.S., BURGESS A.W., SIMPSON R.J.;
RT   "A two-dimensional gel database of human colon carcinoma proteins.";
RL   ELECTROPHORESIS 18:605-613(1997).
CC   -!- FUNCTION: ASSOCIATED WITH NUCLEOLAR RIBONUCLEOPROTEIN STRUCTURES
CC       AND BIND SINGLE-STRANDED NUCLEIC ACIDS. IT MAY FUNCTION IN THE
CC       ASSEMBLY AND/OR TRANSPORT OF RIBOSOME.
CC   -!- SUBUNIT: DISULFIDE-LINKED DIMERS UNDER CERTAIN CONDITIONS.
CC   -!- SUBCELLULAR LOCATION: NUCLEAR. GENERALLY NUCLEOLAR, BUT IS
CC       TRANSLOCATED TO THE NUCLEOPLASM IN CASE OF SERUM STARVATION OR
CC       TREATMENT WITH ANTICANCER DRUGS.
CC   -!- PTM: PHOSPHORYLATED.
CC   -!- DISEASE: A FORM OF NON-HODGKIN'S LYMPHOMA IS CHARACTERIZED BY A
CC       CHROMOSOMAL TRANSLOCATION T(2;5)(P23;Q35) THAT INVOLVES NPM AND
CC       ALK.
CC   -!- DISEASE: A FORM OF ACUTE PROMYELOCYTIC LEUKEMIA IS CHARACTERIZED
CC       BY A CHROMOSOMAL TRANSLOCATION T(5;17)(Q32;Q11) THAT INVOLVES NPM
CC       AND RARA.
CC   -!- SIMILARITY: TO OTHER VERTEBRATE NPM AND TO NUCLEOPLASMIN.
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DR   EMBL; M23613; G189272; -.
DR   EMBL; M28699; G557546; -.
DR   EMBL; M26697; G189312; -.
DR   EMBL; U89321; G2745723; -.
DR   EMBL; U89309; G2745723; JOINED.
DR   EMBL; U89310; G2745723; JOINED.
DR   EMBL; U89311; G2745723; JOINED.
DR   EMBL; U89313; G2745723; JOINED.
DR   EMBL; U89314; G2745723; JOINED.
DR   EMBL; U89317; G2745723; JOINED.
DR   EMBL; U89319; G2745723; JOINED.
DR   EMBL; X16934; G825671; -.
DR   EMBL; J02590; G190238; -.
DR   EMBL; M31004; G190240; ALT_SEQ.
DR   EMBL; U04946; G609342; ALT_TERM.
DR   EMBL; D45915; G1483131; ALT_TERM.
DR   EMBL; U41742; G1314308; ALT_TERM.
DR   EMBL; U41743; G1314310; ALT_TERM.
DR   PIR; A30137; A30137.
DR   PIR; A32915; A32915.
DR   PIR; A26080; A26080.
DR   PIR; B26080; B26080.
DR   PIR; S06926; S06926.
DR   PIR; A33423; A33423.
DR   MIM; 164040; -.
DR   SWISS-2DPAGE; P06748; HUMAN.
KW   NUCLEAR PROTEIN; PHOSPHORYLATION; RNA-BINDING; PROTO-ONCOGENE;
KW   CHROMOSOMAL TRANSLOCATION.
FT   DOMAIN        1      9       MET-RICH.
FT   DOMAIN      120    132       ASP/GLU-RICH (ACIDIC).
FT   DOMAIN      152    157       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT   DOMAIN      161    188       ASP/GLU-RICH (HIGHLY ACIDIC).
FT   DOMAIN      191    197       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT   MOD_RES     125    125       PHOSPHORYLATION.
FT   MOD_RES     199    199       PHOSPHORYLATION.
FT   CONFLICT    129    129       E -> D (IN REF. 10).
FT   CONFLICT    213    213       D -> P (IN G190238).
FT   CONFLICT    216    216       P -> S (IN G190238).
FT   CONFLICT    219    221       TPR -> SSS (IN G190238).
SQ   SEQUENCE   294 AA;  32575 MW;  68223CFE CRC32;

NPM_HUMAN  Length: 294  October 15, 2000 21:30  Type: P  Check: 6645  ..

1  MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG

51  AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL

101  RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK

151  VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP

201  AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK

251  MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL

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