LOCUS NPM_HUMAN 294 aa PRI 30-MAY-2000
DEFINITION NUCLEOPHOSMIN (NPM) (NUCLEOLAR PHOSPHOPROTEIN B23) (NUMATRIN)
(NUCLEOLAR PROTEIN NO38).
ACCESSION P06748
PID g114762
VERSION P06748 GI:114762
DBSOURCE swissprot: locus NPM_HUMAN, accession P06748;
class: standard.
extra accessions:P08693,Q12826,Q14115,Q13440,Q13441,created: Jan 1,
1988.
sequence updated: Nov 1, 1990.
annotation updated: May 30, 2000.
xrefs: gi: 189271, gi: 189272, gi: 557545, gi: 557546, gi: 189311,
gi: 189312, gi: 2745720, gi: 2745723, gi: 2745708, gi: 2745709, gi:
2745710, gi: 2745712, gi: 2745713, gi: 2745716, gi: 2745718, gi:
32029, gi: 825671, gi: 190237, gi: 190238, gi: 190239, gi: 190240,
gi: 609341, gi: 609342, gi: 1483130, gi: 1483131, gi: 1314307, gi:
1314308, gi: 1314309, gi: 1314310, gi: 88281, gi: 107221, gi:
88279, gi: 88280, gi: 88278, gi: 105403
xrefs (non-sequence databases): SWISS-2DPAGE P06748, MIM 164040
KEYWORDS Nuclear protein; Phosphorylation; RNA-binding; Proto-oncogene;
Chromosomal translocation.
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 294)
AUTHORS Chan,W.Y., Liu,Q.R., Borjigin,J., Busch,H., Rennert,O.M.,
Tease,L.A. and Chan,P.K.
TITLE Characterization of the cDNA encoding human nucleophosmin and
studies of its role in normal and abnormal growth
JOURNAL Biochemistry 28 (3), 1033-1039 (1989)
MEDLINE 89229105
REMARK SEQUENCE FROM N.A.
REFERENCE 2 (residues 1 to 294)
AUTHORS Li,X.Z., McNeilage,L.J. and Whittingham,S.
TITLE The nucleotide sequence of a human cDNA encoding the highly
conserved nucleolar phosphoprotein B23
JOURNAL Biochem. Biophys. Res. Commun. 163 (1), 72-78 (1989)
MEDLINE 89374300
REMARK SEQUENCE FROM N.A.
REFERENCE 3 (residues 1 to 294)
AUTHORS Zhang,X.X., Thomis,D.C. and Samuel,C.E.
TITLE Isolation and characterization of a molecular cDNA clone of a human
mRNA from interferon-treated cells encoding nucleolar protein B23,
numatrin
JOURNAL Biochem. Biophys. Res. Commun. 164 (1), 176-184 (1989)
MEDLINE 90026373
REMARK SEQUENCE FROM N.A.
REFERENCE 4 (residues 1 to 294)
AUTHORS Chan,P.K., Chan,F.Y., Morris,S.W. and Xie,Z.
TITLE Isolation and characterization of the human nucleophosmin/B23 (NPM)
gene: identification of the YY1 binding site at the 5' enhancer
region
JOURNAL Nucleic Acids Res. 25 (6), 1225-1232 (1997)
MEDLINE 97248692
REMARK SEQUENCE FROM N.A.
REFERENCE 5 (residues 1 to 294)
AUTHORS Hale,T.K. and Mansfield,B.C.
TITLE Nucleotide sequence of a cDNA clone representing a third allele of
human protein B23
JOURNAL Nucleic Acids Res. 17 (23), 10112 (1989)
MEDLINE 90098787
REMARK SEQUENCE OF 15-294 FROM N.A.
REFERENCE 6 (residues 1 to 294)
AUTHORS Chan,P.K., Chan,W.Y., Yung,B.Y., Cook,R.G., Aldrich,M.B., Ku,D.,
Goldknopf,I.L. and Busch,H.
TITLE Amino acid sequence of a specific antigenic peptide of protein B23
JOURNAL J. Biol. Chem. 261 (30), 14335-14341 (1986)
MEDLINE 87033628
REMARK SEQUENCE OF 213-294 FROM N.A.
REFERENCE 7 (residues 1 to 294)
AUTHORS Morris,S.W., Kirstein,M.N., Valentine,M.B., Dittmer,K.G.,
Shapiro,D.N., Saltman,D.L. and Look,A.T.
TITLE Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in
non-Hodgkin's lymphoma
JOURNAL Science 263 (5151), 1281-1284 (1994)
MEDLINE 94167588
REMARK SEQUENCE OF 1-117 FROM N.A.
TISSUE=LYMPHOMA
Erratum:[[published erratum appears in Science 1995 Jan
20;267(5196):316-7]]
REFERENCE 8 (residues 1 to 294)
AUTHORS Fujimoto,J., Shiota,M., Iwahara,T., Seki,N., Satoh,H., Mori,S. and
Yamamoto,T.
TITLE Characterization of the transforming activity of p80, a
hyperphosphorylated protein in a Ki-1 lymphoma cell line with
chromosomal translocation t(2;5)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (9), 4181-4186 (1996)
MEDLINE 96210614
REMARK SEQUENCE OF 1-117 FROM N.A.
REFERENCE 9 (residues 1 to 294)
AUTHORS Redner,R.L., Rush,E.A., Faas,S., Rudert,W.A. and Corey,S.J.
TITLE The t(5;17) variant of acute promyelocytic leukemia expresses a
nucleophosmin-retinoic acid receptor fusion
JOURNAL Blood 87 (3), 882-886 (1996)
MEDLINE 96151966
REMARK SEQUENCE OF 1-133 FROM N.A.
TISSUE=BONE MARROW
REFERENCE 10 (residues 1 to 294)
AUTHORS Chan,P.K., Aldrich,M., Cook,R.G. and Busch,H.
TITLE Amino acid sequence of protein B23 phosphorylation site
JOURNAL J. Biol. Chem. 261 (4), 1868-1872 (1986)
MEDLINE 86111864
REMARK SEQUENCE OF 115-134.
REFERENCE 11 (residues 1 to 294)
AUTHORS Ji,H., Reid,G.E., Moritz,R.L., Eddes,J.S., Burgess,A.W. and
Simpson,R.J.
TITLE A two-dimensional gel database of human colon carcinoma proteins
JOURNAL Electrophoresis 18 (3-4), 605-613 (1997)
MEDLINE 97295306
REMARK SEQUENCE OF 33-54.
TISSUE=COLON CARCINOMA
COMMENT On Oct 10, 1997 this sequence version replaced gi:231620.
-------------------------------------------------------------------
This SWISS-PROT entry is copyright. It is produced through a
collaboration between the Swiss Institute of Bioinformatics and
the EMBL outstation - the European Bioinformatics Institute.
The original entry is available from http://www.expasy.ch/sprot
and http://www.ebi.ac.uk/sprot
------------------------------------------------------------------.
[FUNCTION] ASSOCIATED WITH NUCLEOLAR RIBONUCLEOPROTEIN STRUCTURES
AND BIND SINGLE-STRANDED NUCLEIC ACIDS. IT MAY FUNCTION IN THE
ASSEMBLY AND/OR TRANSPORT OF RIBOSOME.
[SUBUNIT] DISULFIDE-LINKED DIMERS UNDER CERTAIN CONDITIONS.
[SUBCELLULAR LOCATION] NUCLEAR. GENERALLY NUCLEOLAR, BUT IS
TRANSLOCATED TO THE NUCLEOPLASM IN CASE OF SERUM STARVATION OR
TREATMENT WITH ANTICANCER DRUGS.
[PTM] PHOSPHORYLATED.
[DISEASE] A FORM OF NON-HODGKIN'S LYMPHOMA IS CHARACTERIZED BY A
CHROMOSOMAL TRANSLOCATION T(2;5)(P23;Q35) THAT INVOLVES NPM AND
ALK.
[DISEASE] A FORM OF ACUTE PROMYELOCYTIC LEUKEMIA IS CHARACTERIZED
BY A CHROMOSOMAL TRANSLOCATION T(5;17)(Q32;Q11) THAT INVOLVES NPM
AND RARA.
[SIMILARITY] BELONGS TO THE NUCLEOPLASMIN FAMILY.
FEATURES Location/Qualifiers
source 1..294
/organism="Homo sapiens"
/db_xref="taxon:9606"
Region 1..9
/region_name="Domain"
/note="MET-RICH."
1..294
Protein 1..294
/product="NUCLEOPHOSMIN"
Region 120..132
/region_name="Domain"
/note="ASP/GLU-RICH (ACIDIC)."
Site 125
/site_type="phosphorylation"
Region 129
/region_name="Conflict"
/note="E -> D (IN REF. 10)."
Region 152..157
/region_name="Domain"
/note="NUCLEAR LOCALIZATION SIGNAL (POTENTIAL)."
Region 161..188
/region_name="Domain"
/note="ASP/GLU-RICH (HIGHLY ACIDIC)."
Region 191..197
/region_name="Domain"
/note="NUCLEAR LOCALIZATION SIGNAL (POTENTIAL)."
Site 199
/site_type="phosphorylation"
Region 213
/region_name="Conflict"
/note="D -> P (IN AAA36473)."
Region 216
/region_name="Conflict"
/note="P -> S (IN AAA36473)."
Region 219..221
/region_name="Conflict"
/note="TPR -> SSS (IN AAA36473)."
ORIGIN
1 medsmdmdms plrpqnylfg celkadkdyh fkvdndeneh qlslrtvslg agakdelhiv
61 eaeamnyegs pikvtlatlk msvqptvslg gfeitppvvl rlkcgsgpvh isgqhlvave
121 edaesedeee edvkllsisg krsapgggsk vpqkkvklaa deddddddee dddedddddd
181 fddeeaeeka pvkksirdtp aknaqksnqn gkdskpsstp rskgqesfkk qektpktpkg
241 pssvedikak mqasiekggs lpkveakfin yvkncfrmtd qeaiqdlwqw rksl
//
