BLAST Search Results

BLAST Search Results
Page 1 of 2
TBLASTN 2.0.8 [Jan-05-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query = npm_human.sw
         (294 letters)

Database: genembl
           646,344 sequences; 1,405,317,327 total letters

Sequence	Strand	Description	Score (Bits)	E Value
GB_PR:HUMB23A alignment	+	M28699 Homo sapiens nucleolar phosphoprotein B23... 486 e-136	486	e-136
GB_PR:HUMNUMB23 alignment	+	M26697 Human nucleolar protein (B23) mRNA, com... 486 e-136	486	e-136
GB_PR:HUMNPM alignment	+	M23613 Human nucleophosmin mRNA, complete cds. 10... 486 e-136	486	e-136
GB_RO:MUSN038A alignment	+	M33212 Mouse nucleolar protein N038 mRNA, comple... 467 e-130	467	e-130
GB_RO:RATB23NP alignment	+	J03969 Rat nucleolar protein B23 mRNA, complete ... 467 e-130	467	e-130
GB_RO:RATB23B alignment	+	M25062 Rat nucleolar protein B23.1 mRNA, complete... 467 e-130	467	e-130
GB_PR:HSHB23 alignment	+	X16934 Human hB23 gene for B23 nucleophosmin. 7/1995 457 e-127	457	e-127
GB_HTG:AC007068 alignment	+	AC007068 Homo sapiens clone RPCI11-75L1, WORKI... 354 e-114	354	e-114
GB_PR:AC004941 alignment	+	AC004941 Homo sapiens PAC clone DJ0979P20 from ... 391 e-107	391	e-107
GB_RO:RATB23A alignment	+	J04943 Rat nucleolar protein B23.2 mRNA, complete... 388 e-106	388	e-106
GB_HTG:AC006078 alignment	-	AC006078 Homo sapiens Chromosome 11q12.2 PAC c...	237	6e-92
GB_PR:HSU70984 alignment	-	U70984 Human Xp22 cosmids U106G5 and U26C6, com...	298	1e-91
GB_HTG:AC004127 alignment	-	AC004127 Homo sapiens Chromosome 11q12 pac pDJ...	332	7e-90
GB_OV:GGNPNO38 alignment	+	X17200 Chicken mRNA for nucleolar protein No38 (...	330	3e-89
GB_HTG:HS696P19 alignment	+	AL035588 Human DNA sequence *** SEQUENCING IN ...	164	7e-86
GB_PR:HUMDYSTRO alignment	-	M81257 Human dystrophin gene, exon 44. 11/1994	305	9e-82
GB_OV:XLNO38 alignment	+	X05496 Xenopus laevis mRNA for nucleolar protein N...	300	4e-80
GB_OV:XLNLPNO38 alignment	+	X56039 X.laevis mRNA for nucleolar-localized pr...	300	5e-80
GB_PR:HUMNUCPHOD alignment	+	L15318 Homo sapiens (clone NG5-4) processed p...	122	2e-79
GB_PR:HUMNUCPHOE alignment	+	L15319 Homo sapiens (clone NG6-4) processed p...	160	6e-78
GB_PR:AC005192 alignment	+	AC005192 Homo sapiens BAC clone RG163K11 from 7...	229	1e-73
GB_HTG:HS616B8 alignment	-	AL023803 Human DNA sequence *** SEQUENCING IN P...	258	2e-67
GB_PR:HSU04946 alignment	+	U04946 Human nucleophosmin-anaplastic lymphoma ...	240	5e-62
GB_PR:HSU41742 alignment	+	U41742 Human nucleophosmin-retinoic acid recept...	240	5e-62
GB_PR:HSU41743 alignment	+	U41743 Human nucleophosmin-retinoic acid recept...	240	5e-62
GB_PR:D45915 alignment	+	D45915 Human mRNA for p80 protein, complete cds. ...	240	5e-62
GB_PR:HUMNUCPHOF alignment	+	L15320 Homo sapiens (clone NG7-6) processed p...	160	2e-55
GB_STS:HUMUT1833 alignment	-	L17895 Human STS UT1833, sequence tagged site....	142	3e-51
GB_PR:HUMNUCPHOB alignment	+	L15316 Homo sapiens (clone NG3-3) processed p...	180	9e-51
GB_OM:MRU59897 alignment	+	U59897 Macropus robustus hypoxanthine phosphorib...	200	4e-50
GB_PR:AC005569 alignment	-	AC005569 Homo sapiens chromosome 16, cosmid clo...	178	6e-50
GB_PR:HUMPPB23O alignment	+	M31004 Human nuclear phosphoprotein B23 mRNA, ...	169	1e-40
GB_PR:HUMPPB23N alignment	+	J02590 Human nucleolar phosphoprotein B23 mRNA...	159	1e-37
GB_OV:CHKNP1 alignment	+	J03164 Chicken nucleolar protein B23/No38 mRNA, 5'...	158	2e-37
GB_PR:HS244F1 alignment	+	AL021330 Human DNA sequence from PAC 244F1 on ch...	96	5e-37
GB_PR:AC004994 alignment	+	AC004994 Homo sapiens PAC clone DJ1194E15 from ...	124	2e-36
GB_PR:AC004538 alignment	-	AC004538 Homo sapiens PAC clone DJ0887P04 from ...	117	2e-35
GB_PR:HSNG26 alignment	+	X54171 H.sapiens NG2-6 DNA. 5/1992	87	3e-26
GB_OV:XLNOVA alignment	+	Z85983 X.laevis mRNA for NOVA protein. 9/1997	106	1e-21
GB_OV:XLNUPLR2 alignment	+	X04766 Xenopus laevis mRNA for nucleoplasmin. 9/...	105	2e-21
GB_PR:HUMNUCPHOA alignment	+	L15315 Homo sapiens (clone NG1-6) processed p...	104	3e-21
GB_OV:XLNUPLR alignment	+	Y00204 Xenopus laevis mRNA fragment for nucleopla...	102	1e-20
GB_PR:AF081280 alignment	+	AF081280 Homo sapiens nucleoplasmin-3 (NPM3) mR...	96	1e-18
GB_RO:MMU67172 alignment	+	U67172 Mus musculus nucleophosmin/nucleoplasmin-...	94	6e-18
GB_HTG:AC007174 alignment	+	AC007174 Homo sapiens, clone hRPK.93_A_1, WORK...	94	7e-18
GB_RO:MMU64450 alignment	+	U64450 Mus musculus nucleophosmin/nucleoplasmin-...	92	3e-17
GB_PR:HUMNUCPHOC alignment	+	L15317 Homo sapiens (clone NG4-5) processed p...	85	7e-17
GB_PR:AC007159 alignment	+	AC007159 Homo sapiens, clone 2_A_4, complete se...	83	9e-17
GB_RO:RATNUCBA2 alignment	+	M37036 Rat nucleolar proteins B23.1 and B23.2. ...	84	6e-15
GB_PR:HSMNPP03 alignment	+	U89311 Homo sapiens nucleophosmin phosphoprotei...	82	2e-14


Run Parameters
  Database: genembl
    Posted date:  Apr 19, 1999 12:08 PM
  Number of letters in database: 1,405,317,327
  Number of sequences in database:  646,344
  
Lambda     K      H
   0.310    0.129    0.365 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 380120486
Number of Sequences: 646344
Number of extensions: 4401319
Number of successful extensions: 20620
Number of sequences better than 10.0: 154
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 20375
Number of HSP's gapped (non-prelim): 198
length of query: 294
length of database: 468439109
effective HSP length: 63
effective length of query: 231
effective length of database: 427719437
effective search space: 98803189947
effective search space used: 98803189947
frameshift window, decay const: 50,  0.1
T: 13
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.8 bits)
S2: 74 (33.2 bits)

Input Sequence: npm_human.sw

!!AA_SEQUENCE 1.0
ID   NPM_HUMAN      STANDARD;      PRT;   294 AA.
AC   P06748; P08693; Q12826; Q14115; Q13440; Q13441;
DT   01-JAN-1988 (REL. 06, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   NUCLEOPHOSMIN (NPM) (NUCLEOLAR PHOSPHOPROTEIN B23) (NUMATRIN)
DE   (NUCLEOLAR PROTEIN NO38).
GN   NPM1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89229105.
RA   CHAN W.Y., LIU Q.R., BORJIGIN J., BUSCH H., RENNERT O.M., TEASE L.A.,
RA   CHAN P.-K.;
RT   "Characterization of the cDNA encoding human nucleophosmin and
RT   studies of its role in normal and abnormal growth.";
RL   BIOCHEMISTRY 28:1033-1039(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89374300.
RA   LI X., MCNEILAGE L.J., WHITTINGHAM S.;
RT   "The nucleotide sequence of a human cDNA encoding the highly
RT   conserved nucleolar phosphoprotein B23.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 163:72-78(1989).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 90026373.
RA   ZHANG X.T., THOMIS D.C., SAMUEL C.E.;
RT   "Isolation and characterization of a molecular cDNA clone of a human
RT   mRNA from interferon-treated cells encoding nucleolar protein B23,
RT   numatrin.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 164:176-184(1989).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 97248692.
RA   CHAN P.K., CHAN F.Y., MORRIS S.W., XIE Z.;
RT   "Isolation and characterization of the human nucleophosmin/B23 (NPM)
RT   gene: identification of the YY1 binding site at the 5' enhancer
RT   region.";
RL   NUCLEIC ACIDS RES. 25:1225-1232(1997).
RN   [5]
RP   SEQUENCE OF 15-294 FROM N.A. (CLONE HL6T).
RX   MEDLINE; 90098787.
RA   HALE T.K., MANSFIELD B.C.;
RT   "Nucleotide sequence of a cDNA clone representing a third allele of
RT   human protein B23.";
RL   NUCLEIC ACIDS RES. 17:10112-10112(1989).
RN   [6]
RP   SEQUENCE OF 213-294 FROM N.A.
RX   MEDLINE; 87033628.
RA   CHAN P.-K., CHAN W.-Y., YUNG B.Y.M., COOK R.G., ALDRICH M.B.,
RA   KU D., GOLDKNOPF I.L., BUSCH H.;
RT   "Amino acid sequence of a specific antigenic peptide of protein B23.";
RL   J. BIOL. CHEM. 261:14335-14341(1986).
RN   [7]
RP   SEQUENCE OF 1-117 FROM N.A.
RC   TISSUE=LYMPHOMA;
RX   MEDLINE; 94167588.
RA   MORRIS S.W., KIRSTEIN M.N., VALENTINE M.B., DITTMER K.G.,
RA   SHAPIRO D.N., SALTMAN D.L., LOOK A.T.;
RT   "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in
RT   non-Hodgkin's lymphoma.";
RL   SCIENCE 263:1281-1284(1994).
RN   [8]
RP   SEQUENCE OF 1-117 FROM N.A.
RX   MEDLINE; 96210614.
RA   FUJIMOTO J., SHIOTA M., IWAHARA T., SEKI N., SATOH H., MORI S.,
RA   YAMAMOTO T.;
RT   "Characterization of the transforming activity of p80, a
RT   hyperphosphorylated protein in a Ki-1 lymphoma cell line with
RT   chromosomal translocation t(2;5).";
RL   PROC. NATL. ACAD. SCI. U.S.A. 93:4181-4186(1996).
RN   [9]
RP   SEQUENCE OF 1-133 FROM N.A.
RC   TISSUE=BONE MARROW;
RX   MEDLINE; 96151966.
RA   REDNER R.L., RUSH E.A., FAAS S., RUDERT W.A., COREY S.J.;
RT   "The t(5;17) variant of acute promyelocytic leukemia expresses a
RT   nucleophosmin-retinoic acid receptor fusion.";
RL   BLOOD 87:882-886(1996).
RN   [10]
RP   SEQUENCE OF 115-134.
RX   MEDLINE; 86111864.
RA   CHAN P.-K., ALDRICH M.B., COOK R.G., BUSCH H.;
RT   "Amino acid sequence of protein B23 phosphorylation site.";
RL   J. BIOL. CHEM. 261:1868-1872(1986).
RN   [11]
RP   SEQUENCE OF 33-54.
RC   TISSUE=COLON CARCINOMA;
RX   MEDLINE; 97295306.
RA   JI H., REID G.E., MORITZ R.L., EDDES J.S., BURGESS A.W., SIMPSON R.J.;
RT   "A two-dimensional gel database of human colon carcinoma proteins.";
RL   ELECTROPHORESIS 18:605-613(1997).
CC   -!- FUNCTION: ASSOCIATED WITH NUCLEOLAR RIBONUCLEOPROTEIN STRUCTURES
CC       AND BIND SINGLE-STRANDED NUCLEIC ACIDS. IT MAY FUNCTION IN THE
CC       ASSEMBLY AND/OR TRANSPORT OF RIBOSOME.
CC   -!- SUBUNIT: DISULFIDE-LINKED DIMERS UNDER CERTAIN CONDITIONS.
CC   -!- SUBCELLULAR LOCATION: NUCLEAR. GENERALLY NUCLEOLAR, BUT IS
CC       TRANSLOCATED TO THE NUCLEOPLASM IN CASE OF SERUM STARVATION OR
CC       TREATMENT WITH ANTICANCER DRUGS.
CC   -!- PTM: PHOSPHORYLATED.
CC   -!- DISEASE: A FORM OF NON-HODGKIN'S LYMPHOMA IS CHARACTERIZED BY A
CC       CHROMOSOMAL TRANSLOCATION T(2;5)(P23;Q35) THAT INVOLVES NPM AND
CC       ALK.
CC   -!- DISEASE: A FORM OF ACUTE PROMYELOCYTIC LEUKEMIA IS CHARACTERIZED
CC       BY A CHROMOSOMAL TRANSLOCATION T(5;17)(Q32;Q11) THAT INVOLVES NPM
CC       AND RARA.
CC   -!- SIMILARITY: TO OTHER VERTEBRATE NPM AND TO NUCLEOPLASMIN.
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DR   EMBL; M23613; G189272; -.
DR   EMBL; M28699; G557546; -.
DR   EMBL; M26697; G189312; -.
DR   EMBL; U89321; G2745723; -.
DR   EMBL; U89309; G2745723; JOINED.
DR   EMBL; U89310; G2745723; JOINED.
DR   EMBL; U89311; G2745723; JOINED.
DR   EMBL; U89313; G2745723; JOINED.
DR   EMBL; U89314; G2745723; JOINED.
DR   EMBL; U89317; G2745723; JOINED.
DR   EMBL; U89319; G2745723; JOINED.
DR   EMBL; X16934; G825671; -.
DR   EMBL; J02590; G190238; -.
DR   EMBL; M31004; G190240; ALT_SEQ.
DR   EMBL; U04946; G609342; ALT_TERM.
DR   EMBL; D45915; G1483131; ALT_TERM.
DR   EMBL; U41742; G1314308; ALT_TERM.
DR   EMBL; U41743; G1314310; ALT_TERM.
DR   PIR; A30137; A30137.
DR   PIR; A32915; A32915.
DR   PIR; A26080; A26080.
DR   PIR; B26080; B26080.
DR   PIR; S06926; S06926.
DR   PIR; A33423; A33423.
DR   MIM; 164040; -.
DR   SWISS-2DPAGE; P06748; HUMAN.
KW   NUCLEAR PROTEIN; PHOSPHORYLATION; RNA-BINDING; PROTO-ONCOGENE;
KW   CHROMOSOMAL TRANSLOCATION.
FT   DOMAIN        1      9       MET-RICH.
FT   DOMAIN      120    132       ASP/GLU-RICH (ACIDIC).
FT   DOMAIN      152    157       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT   DOMAIN      161    188       ASP/GLU-RICH (HIGHLY ACIDIC).
FT   DOMAIN      191    197       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT   MOD_RES     125    125       PHOSPHORYLATION.
FT   MOD_RES     199    199       PHOSPHORYLATION.
FT   CONFLICT    129    129       E -> D (IN REF. 10).
FT   CONFLICT    213    213       D -> P (IN G190238).
FT   CONFLICT    216    216       P -> S (IN G190238).
FT   CONFLICT    219    221       TPR -> SSS (IN G190238).
SQ   SEQUENCE   294 AA;  32575 MW;  68223CFE CRC32;

NPM_HUMAN  Length: 294  October 15, 2000 21:30  Type: P  Check: 6645  ..

1  MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG

51  AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL

101  RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK

151  VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP

201  AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK

251  MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL

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