BLAST Search Results

BLAST Search Results
Page 2 of 2
TBLASTN 2.0.8 [Jan-05-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query = npm_human.sw
         (294 letters)

Database: genembl
           646,344 sequences; 1,405,317,327 total letters

Sequence	Strand	Description	Score (Bits)	E Value
GB_PR:HSMNPP09 alignment	+	U89317 Homo sapiens nucleophosmin phosphoprotei...	71	3e-11
GB_RO:RATNUCBA4 alignment	+	M37038 Rat nucleolar proteins B23.1 and B23.2. ...	71	3e-11
GB_RO:RATB23 alignment	+	J04944 Rat nucleolar protein B23.2 gene, complete ...	71	3e-11
GB_PR:S82740 alignment	+	S82740 NPM/ALK=fusion gene {translocation breakpo...	65	3e-09
GB_PR:S82725 alignment	+	S82725 NPM/ALK=fusion gene {translocation breakpo...	65	3e-09
GB_PR:HSMNPP02 alignment	+	U89310 Homo sapiens nucleophosmin phosphoprotei...	64	6e-09
GB_PR:HSMNPP06 alignment	+	U89314 Homo sapiens nucleophosmin phosphoprotei...	62	2e-08
GB_IN:LPU76750 alignment	+	U76750 Lytechinus pictus mitotic apparatus prot...	62	2e-08
GB_OV:CHKNP2 alignment	+	J03165 Chicken nucleolar protein B23/No38 mRNA, 3'...	58	3e-07
GB_PR:HSMNPP11 alignment	+	U89319 Homo sapiens nucleophosmin phosphoprotei...	58	4e-07
GB_RO:RATNUCBA6 alignment	+	M37040 Rat nucleolar proteins B23.1 and B23.2. ...	57	8e-07
GB_RO:RATNUCBA3 alignment	+	M37037 Rat nucleolar proteins B23.1 and B23.2. ...	53	9e-06
GB_PR:HSMNPP01 alignment	+	U89309 Homo sapiens nucleophosmin phosphoprotei...	46	0.001
GB_RO:RATNUCBA1 alignment	+	M37035 Rat nucleolar proteins B23.1 and B23.2. ...	46	0.001
GB_IN:DMU59498 alignment	+	U59498 Drosophila melanogaster nucleoplasmin-li...	37	0.73
GB_IN:CEU33058 alignment	+	U33058 Caenorhabditis elegans UNC-89 (unc-89) g...	37	0.96
GB_HTG:AC006780 alignment	+	AC006780 Caenorhabditis elegans clone Y47D9A, ...	37	0.96
GB_HTG:AC006858 alignment	+	AC006858 Caenorhabditis elegans clone Y47D9X, ...	37	0.96
GB_IN:CELC09D1 alignment	+	AF003131 Caenorhabditis elegans cosmid C09D1. 5...	37	0.96
GB_IN:DMCRP1 alignment	+	X99293 D.melanogaster mRNA for CRP1 protein. 7/1996	36	2.1
GB_OM:AF091342 alignment	+	AF091342 Bos taurus neurofilament-M subunit (NF-...	35	2.8
GB_PL:OSU07338 alignment	+	U07338 Oryza sativa pyruvate decarboxylase (pdc...	35	3.7
GB_PR:HSU18985 alignment	+	U18985 Human triadin mRNA, complete cds. 9/1995	34	4.8
GB_PR:AC005263 alignment	-	AC005263 Homo sapiens chromosome 19, cosmid F20...	34	8.3
GB_PL:SCU40082 alignment	-	U40082 Saccharomycopsis capsularis 26S ribosoma...	34	8.3
GB_RO:RATNUCBA7 alignment	+	M37041 Rat nucleolar proteins B23.1 and B23.2. ...	34	8.3
GB_PR:AC004490 alignment	-	AC004490 Homo sapiens chromosome 19, cosmid R29...	34	8.3


Run Parameters
  Database: genembl
    Posted date:  Apr 19, 1999 12:08 PM
  Number of letters in database: 1,405,317,327
  Number of sequences in database:  646,344
  
Lambda     K      H
   0.310    0.129    0.365 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 380120486
Number of Sequences: 646344
Number of extensions: 4401319
Number of successful extensions: 20620
Number of sequences better than 10.0: 154
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 20375
Number of HSP's gapped (non-prelim): 198
length of query: 294
length of database: 468439109
effective HSP length: 63
effective length of query: 231
effective length of database: 427719437
effective search space: 98803189947
effective search space used: 98803189947
frameshift window, decay const: 50,  0.1
T: 13
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.8 bits)
S2: 74 (33.2 bits)

Input Sequence: npm_human.sw

!!AA_SEQUENCE 1.0
ID   NPM_HUMAN      STANDARD;      PRT;   294 AA.
AC   P06748; P08693; Q12826; Q14115; Q13440; Q13441;
DT   01-JAN-1988 (REL. 06, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   NUCLEOPHOSMIN (NPM) (NUCLEOLAR PHOSPHOPROTEIN B23) (NUMATRIN)
DE   (NUCLEOLAR PROTEIN NO38).
GN   NPM1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89229105.
RA   CHAN W.Y., LIU Q.R., BORJIGIN J., BUSCH H., RENNERT O.M., TEASE L.A.,
RA   CHAN P.-K.;
RT   "Characterization of the cDNA encoding human nucleophosmin and
RT   studies of its role in normal and abnormal growth.";
RL   BIOCHEMISTRY 28:1033-1039(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89374300.
RA   LI X., MCNEILAGE L.J., WHITTINGHAM S.;
RT   "The nucleotide sequence of a human cDNA encoding the highly
RT   conserved nucleolar phosphoprotein B23.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 163:72-78(1989).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 90026373.
RA   ZHANG X.T., THOMIS D.C., SAMUEL C.E.;
RT   "Isolation and characterization of a molecular cDNA clone of a human
RT   mRNA from interferon-treated cells encoding nucleolar protein B23,
RT   numatrin.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 164:176-184(1989).
RN   [4]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 97248692.
RA   CHAN P.K., CHAN F.Y., MORRIS S.W., XIE Z.;
RT   "Isolation and characterization of the human nucleophosmin/B23 (NPM)
RT   gene: identification of the YY1 binding site at the 5' enhancer
RT   region.";
RL   NUCLEIC ACIDS RES. 25:1225-1232(1997).
RN   [5]
RP   SEQUENCE OF 15-294 FROM N.A. (CLONE HL6T).
RX   MEDLINE; 90098787.
RA   HALE T.K., MANSFIELD B.C.;
RT   "Nucleotide sequence of a cDNA clone representing a third allele of
RT   human protein B23.";
RL   NUCLEIC ACIDS RES. 17:10112-10112(1989).
RN   [6]
RP   SEQUENCE OF 213-294 FROM N.A.
RX   MEDLINE; 87033628.
RA   CHAN P.-K., CHAN W.-Y., YUNG B.Y.M., COOK R.G., ALDRICH M.B.,
RA   KU D., GOLDKNOPF I.L., BUSCH H.;
RT   "Amino acid sequence of a specific antigenic peptide of protein B23.";
RL   J. BIOL. CHEM. 261:14335-14341(1986).
RN   [7]
RP   SEQUENCE OF 1-117 FROM N.A.
RC   TISSUE=LYMPHOMA;
RX   MEDLINE; 94167588.
RA   MORRIS S.W., KIRSTEIN M.N., VALENTINE M.B., DITTMER K.G.,
RA   SHAPIRO D.N., SALTMAN D.L., LOOK A.T.;
RT   "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in
RT   non-Hodgkin's lymphoma.";
RL   SCIENCE 263:1281-1284(1994).
RN   [8]
RP   SEQUENCE OF 1-117 FROM N.A.
RX   MEDLINE; 96210614.
RA   FUJIMOTO J., SHIOTA M., IWAHARA T., SEKI N., SATOH H., MORI S.,
RA   YAMAMOTO T.;
RT   "Characterization of the transforming activity of p80, a
RT   hyperphosphorylated protein in a Ki-1 lymphoma cell line with
RT   chromosomal translocation t(2;5).";
RL   PROC. NATL. ACAD. SCI. U.S.A. 93:4181-4186(1996).
RN   [9]
RP   SEQUENCE OF 1-133 FROM N.A.
RC   TISSUE=BONE MARROW;
RX   MEDLINE; 96151966.
RA   REDNER R.L., RUSH E.A., FAAS S., RUDERT W.A., COREY S.J.;
RT   "The t(5;17) variant of acute promyelocytic leukemia expresses a
RT   nucleophosmin-retinoic acid receptor fusion.";
RL   BLOOD 87:882-886(1996).
RN   [10]
RP   SEQUENCE OF 115-134.
RX   MEDLINE; 86111864.
RA   CHAN P.-K., ALDRICH M.B., COOK R.G., BUSCH H.;
RT   "Amino acid sequence of protein B23 phosphorylation site.";
RL   J. BIOL. CHEM. 261:1868-1872(1986).
RN   [11]
RP   SEQUENCE OF 33-54.
RC   TISSUE=COLON CARCINOMA;
RX   MEDLINE; 97295306.
RA   JI H., REID G.E., MORITZ R.L., EDDES J.S., BURGESS A.W., SIMPSON R.J.;
RT   "A two-dimensional gel database of human colon carcinoma proteins.";
RL   ELECTROPHORESIS 18:605-613(1997).
CC   -!- FUNCTION: ASSOCIATED WITH NUCLEOLAR RIBONUCLEOPROTEIN STRUCTURES
CC       AND BIND SINGLE-STRANDED NUCLEIC ACIDS. IT MAY FUNCTION IN THE
CC       ASSEMBLY AND/OR TRANSPORT OF RIBOSOME.
CC   -!- SUBUNIT: DISULFIDE-LINKED DIMERS UNDER CERTAIN CONDITIONS.
CC   -!- SUBCELLULAR LOCATION: NUCLEAR. GENERALLY NUCLEOLAR, BUT IS
CC       TRANSLOCATED TO THE NUCLEOPLASM IN CASE OF SERUM STARVATION OR
CC       TREATMENT WITH ANTICANCER DRUGS.
CC   -!- PTM: PHOSPHORYLATED.
CC   -!- DISEASE: A FORM OF NON-HODGKIN'S LYMPHOMA IS CHARACTERIZED BY A
CC       CHROMOSOMAL TRANSLOCATION T(2;5)(P23;Q35) THAT INVOLVES NPM AND
CC       ALK.
CC   -!- DISEASE: A FORM OF ACUTE PROMYELOCYTIC LEUKEMIA IS CHARACTERIZED
CC       BY A CHROMOSOMAL TRANSLOCATION T(5;17)(Q32;Q11) THAT INVOLVES NPM
CC       AND RARA.
CC   -!- SIMILARITY: TO OTHER VERTEBRATE NPM AND TO NUCLEOPLASMIN.
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DR   EMBL; M23613; G189272; -.
DR   EMBL; M28699; G557546; -.
DR   EMBL; M26697; G189312; -.
DR   EMBL; U89321; G2745723; -.
DR   EMBL; U89309; G2745723; JOINED.
DR   EMBL; U89310; G2745723; JOINED.
DR   EMBL; U89311; G2745723; JOINED.
DR   EMBL; U89313; G2745723; JOINED.
DR   EMBL; U89314; G2745723; JOINED.
DR   EMBL; U89317; G2745723; JOINED.
DR   EMBL; U89319; G2745723; JOINED.
DR   EMBL; X16934; G825671; -.
DR   EMBL; J02590; G190238; -.
DR   EMBL; M31004; G190240; ALT_SEQ.
DR   EMBL; U04946; G609342; ALT_TERM.
DR   EMBL; D45915; G1483131; ALT_TERM.
DR   EMBL; U41742; G1314308; ALT_TERM.
DR   EMBL; U41743; G1314310; ALT_TERM.
DR   PIR; A30137; A30137.
DR   PIR; A32915; A32915.
DR   PIR; A26080; A26080.
DR   PIR; B26080; B26080.
DR   PIR; S06926; S06926.
DR   PIR; A33423; A33423.
DR   MIM; 164040; -.
DR   SWISS-2DPAGE; P06748; HUMAN.
KW   NUCLEAR PROTEIN; PHOSPHORYLATION; RNA-BINDING; PROTO-ONCOGENE;
KW   CHROMOSOMAL TRANSLOCATION.
FT   DOMAIN        1      9       MET-RICH.
FT   DOMAIN      120    132       ASP/GLU-RICH (ACIDIC).
FT   DOMAIN      152    157       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT   DOMAIN      161    188       ASP/GLU-RICH (HIGHLY ACIDIC).
FT   DOMAIN      191    197       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT   MOD_RES     125    125       PHOSPHORYLATION.
FT   MOD_RES     199    199       PHOSPHORYLATION.
FT   CONFLICT    129    129       E -> D (IN REF. 10).
FT   CONFLICT    213    213       D -> P (IN G190238).
FT   CONFLICT    216    216       P -> S (IN G190238).
FT   CONFLICT    219    221       TPR -> SSS (IN G190238).
SQ   SEQUENCE   294 AA;  32575 MW;  68223CFE CRC32;

NPM_HUMAN  Length: 294  October 15, 2000 21:30  Type: P  Check: 6645  ..

1  MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG

51  AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL

101  RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK

151  VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP

201  AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK

251  MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL

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