!!AA_SEQUENCE 1.0
ID NPM_HUMAN STANDARD; PRT; 294 AA.
AC P06748; P08693; Q12826; Q14115; Q13440; Q13441;
DT 01-JAN-1988 (REL. 06, CREATED)
DT 01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE NUCLEOPHOSMIN (NPM) (NUCLEOLAR PHOSPHOPROTEIN B23) (NUMATRIN)
DE (NUCLEOLAR PROTEIN NO38).
GN NPM1.
OS HOMO SAPIENS (HUMAN).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 89229105 [NCBI] [Geneva].
RA CHAN W.Y., LIU Q.R., BORJIGIN J., BUSCH H., RENNERT O.M., TEASE L.A.,
RA CHAN P.-K.;
RT "Characterization of the cDNA encoding human nucleophosmin and
RT studies of its role in normal and abnormal growth.";
RL BIOCHEMISTRY 28:1033-1039(1989).
RN [2]
RP SEQUENCE FROM N.A.
RX MEDLINE; 89374300 [NCBI] [Geneva].
RA LI X., MCNEILAGE L.J., WHITTINGHAM S.;
RT "The nucleotide sequence of a human cDNA encoding the highly
RT conserved nucleolar phosphoprotein B23.";
RL BIOCHEM. BIOPHYS. RES. COMMUN. 163:72-78(1989).
RN [3]
RP SEQUENCE FROM N.A.
RX MEDLINE; 90026373 [NCBI] [Geneva].
RA ZHANG X.T., THOMIS D.C., SAMUEL C.E.;
RT "Isolation and characterization of a molecular cDNA clone of a human
RT mRNA from interferon-treated cells encoding nucleolar protein B23,
RT numatrin.";
RL BIOCHEM. BIOPHYS. RES. COMMUN. 164:176-184(1989).
RN [4]
RP SEQUENCE FROM N.A.
RX MEDLINE; 97248692 [NCBI] [Geneva].
RA CHAN P.K., CHAN F.Y., MORRIS S.W., XIE Z.;
RT "Isolation and characterization of the human nucleophosmin/B23 (NPM)
RT gene: identification of the YY1 binding site at the 5' enhancer
RT region.";
RL NUCLEIC ACIDS RES. 25:1225-1232(1997).
RN [5]
RP SEQUENCE OF 15-294 FROM N.A. (CLONE HL6T).
RX MEDLINE; 90098787 [NCBI] [Geneva].
RA HALE T.K., MANSFIELD B.C.;
RT "Nucleotide sequence of a cDNA clone representing a third allele of
RT human protein B23.";
RL NUCLEIC ACIDS RES. 17:10112-10112(1989).
RN [6]
RP SEQUENCE OF 213-294 FROM N.A.
RX MEDLINE; 87033628 [NCBI] [Geneva].
RA CHAN P.-K., CHAN W.-Y., YUNG B.Y.M., COOK R.G., ALDRICH M.B.,
RA KU D., GOLDKNOPF I.L., BUSCH H.;
RT "Amino acid sequence of a specific antigenic peptide of protein B23.";
RL J. BIOL. CHEM. 261:14335-14341(1986).
RN [7]
RP SEQUENCE OF 1-117 FROM N.A.
RC TISSUE=LYMPHOMA;
RX MEDLINE; 94167588 [NCBI] [Geneva].
RA MORRIS S.W., KIRSTEIN M.N., VALENTINE M.B., DITTMER K.G.,
RA SHAPIRO D.N., SALTMAN D.L., LOOK A.T.;
RT "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in
RT non-Hodgkin's lymphoma.";
RL SCIENCE 263:1281-1284(1994).
RN [8]
RP SEQUENCE OF 1-117 FROM N.A.
RX MEDLINE; 96210614 [NCBI] [Geneva].
RA FUJIMOTO J., SHIOTA M., IWAHARA T., SEKI N., SATOH H., MORI S.,
RA YAMAMOTO T.;
RT "Characterization of the transforming activity of p80, a
RT hyperphosphorylated protein in a Ki-1 lymphoma cell line with
RT chromosomal translocation t(2;5).";
RL PROC. NATL. ACAD. SCI. U.S.A. 93:4181-4186(1996).
RN [9]
RP SEQUENCE OF 1-133 FROM N.A.
RC TISSUE=BONE MARROW;
RX MEDLINE; 96151966 [NCBI] [Geneva].
RA REDNER R.L., RUSH E.A., FAAS S., RUDERT W.A., COREY S.J.;
RT "The t(5;17) variant of acute promyelocytic leukemia expresses a
RT nucleophosmin-retinoic acid receptor fusion.";
RL BLOOD 87:882-886(1996).
RN [10]
RP SEQUENCE OF 115-134.
RX MEDLINE; 86111864 [NCBI] [Geneva].
RA CHAN P.-K., ALDRICH M.B., COOK R.G., BUSCH H.;
RT "Amino acid sequence of protein B23 phosphorylation site.";
RL J. BIOL. CHEM. 261:1868-1872(1986).
RN [11]
RP SEQUENCE OF 33-54.
RC TISSUE=COLON CARCINOMA;
RX MEDLINE; 97295306 [NCBI] [Geneva].
RA JI H., REID G.E., MORITZ R.L., EDDES J.S., BURGESS A.W., SIMPSON R.J.;
RT "A two-dimensional gel database of human colon carcinoma proteins.";
RL ELECTROPHORESIS 18:605-613(1997).
CC -!- FUNCTION: ASSOCIATED WITH NUCLEOLAR RIBONUCLEOPROTEIN STRUCTURES
CC AND BIND SINGLE-STRANDED NUCLEIC ACIDS. IT MAY FUNCTION IN THE
CC ASSEMBLY AND/OR TRANSPORT OF RIBOSOME.
CC -!- SUBUNIT: DISULFIDE-LINKED DIMERS UNDER CERTAIN CONDITIONS.
CC -!- SUBCELLULAR LOCATION: NUCLEAR. GENERALLY NUCLEOLAR, BUT IS
CC TRANSLOCATED TO THE NUCLEOPLASM IN CASE OF SERUM STARVATION OR
CC TREATMENT WITH ANTICANCER DRUGS.
CC -!- PTM: PHOSPHORYLATED.
CC -!- DISEASE: A FORM OF NON-HODGKIN'S LYMPHOMA IS CHARACTERIZED BY A
CC CHROMOSOMAL TRANSLOCATION T(2;5)(P23;Q35) THAT INVOLVES NPM AND
CC ALK.
CC -!- DISEASE: A FORM OF ACUTE PROMYELOCYTIC LEUKEMIA IS CHARACTERIZED
CC BY A CHROMOSOMAL TRANSLOCATION T(5;17)(Q32;Q11) THAT INVOLVES NPM
CC AND RARA.
CC -!- SIMILARITY: TO OTHER VERTEBRATE NPM AND TO NUCLEOPLASMIN.
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CC the European Bioinformatics Institute. There are no restrictions on its
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DR EMBL; M23613; G189272; -.
DR EMBL; M28699; G557546; -.
DR EMBL; M26697; G189312; -.
DR EMBL; U89321; G2745723; -.
DR EMBL; U89309; G2745723; JOINED.
DR EMBL; U89310; G2745723; JOINED.
DR EMBL; U89311; G2745723; JOINED.
DR EMBL; U89313; G2745723; JOINED.
DR EMBL; U89314; G2745723; JOINED.
DR EMBL; U89317; G2745723; JOINED.
DR EMBL; U89319; G2745723; JOINED.
DR EMBL; X16934; G825671; -.
DR EMBL; J02590; G190238; -.
DR EMBL; M31004; G190240; ALT_SEQ.
DR EMBL; U04946; G609342; ALT_TERM.
DR EMBL; D45915; G1483131; ALT_TERM.
DR EMBL; U41742; G1314308; ALT_TERM.
DR EMBL; U41743; G1314310; ALT_TERM.
DR PIR; A30137; A30137.
DR PIR; A32915; A32915.
DR PIR; A26080; A26080.
DR PIR; B26080; B26080.
DR PIR; S06926; S06926.
DR PIR; A33423; A33423.
DR MIM; 164040; -.
DR SWISS-2DPAGE; P06748; HUMAN.
KW NUCLEAR PROTEIN; PHOSPHORYLATION; RNA-BINDING; PROTO-ONCOGENE;
KW CHROMOSOMAL TRANSLOCATION.
FT DOMAIN 1 9 MET-RICH.
FT DOMAIN 120 132 ASP/GLU-RICH (ACIDIC).
FT DOMAIN 152 157 NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT DOMAIN 161 188 ASP/GLU-RICH (HIGHLY ACIDIC).
FT DOMAIN 191 197 NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
FT MOD_RES 125 125 PHOSPHORYLATION.
FT MOD_RES 199 199 PHOSPHORYLATION.
FT CONFLICT 129 129 E -> D (IN REF. 10).
FT CONFLICT 213 213 D -> P (IN G190238).
FT CONFLICT 216 216 P -> S (IN G190238).
FT CONFLICT 219 221 TPR -> SSS (IN G190238).
SQ SEQUENCE 294 AA; 32575 MW; 68223CFE CRC32;
NPM_HUMAN Length: 294 October 15, 2000 21:30 Type: P Check: 6645 ..
1 MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
51 AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
101 RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK
151 VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP
201 AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK
251 MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL