Pairwise
Comparsion
Nucleotide sequence alignments
Residues with shared chemical properties can
substitute for each other
Size, charge, hydrophobicity, polarity
scored less than a match, but better than a
mismatch
Conservative changes scored as better than
non-conservative
137
AGACCAACCTGGCCAACATGGTGAAATCCCATCTCTAC.AAAAATACAAA 185
|||||| ||||||||||||||||||| |||||||||| ||||||||||
1 AGACCAGCCTGGCCAACATGGTGAAACTCCATCTCTACTGAAAATACAAA
50
match
mismatch
gap
Protein sequence alignments
Conserved substitution
10 20
30 40 50
60
ggamma.pep
MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
|||||||||||||||||:|||::|||||:|||||:|||||||||||||||||||||||||
HGCZG
MGHFTEEDKATITSLWGHVNVDEAGGETIGRLLVLYPWTQRFFDSFGNLSSASAIMGNPK
10 20
30 40 50 60