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  UniGene Cluster Hs.19192 Homo sapiens

CDK2 Cyclin-dependent kinase 2

SEE ALSO
LocusLink: 1017
OMIM: 116953
HomoloGene: Hs.19192

SELECTED MODEL ORGANISM PROTEIN SIMILARITIES
organism, protein and percent identity and length of aligned region

H.sapiens: pdb:1FVV - A Chain A, The Structure Of Cdk2CYCLIN A IN COMPLEX WITH AN OXINDOLE Inhibitor 100 % / 297 aa
(see ProtEST )
M.musculus: ref:NP_058036.1 - cyclin-dependent kinase 2 [Mus musculus] 98 % / 297 aa
(see ProtEST )
R.norvegicus: sp:Q63699 - CDK2_RAT CELL DIVISION PROTEIN KINASE 2 98 % / 297 aa
(see ProtEST )
A.thaliana: sp:P24100 - CC2A_ARATH CELL DIVISION CONTROL PROTEIN 2 HOMOLOG A 68 % / 288 aa
(see ProtEST )
C.elegans: ref:NP_499153.1 - serine/threonine kinase (CDC2/CDKX subfamily) [Caenorhabditis elegans] 60 % / 288 aa
(see ProtEST )
D.melanogaster: sp:P23573 - CC2C_DROME Cell division control protein 2 cognate 64 % / 297 aa
(see ProtEST )
S.cerevisiae: sp:P00546 - CC28_YEAST CELL DIVISION CONTROL PROTEIN 28 62 % / 287 aa
(see ProtEST )

MAPPING INFORMATION
Chromosome: 12
Genome View: Chromosome 12
OMIM Gene Map: 12q13
Whitehead map: WI-7544, Chr.12
UniSTS entries: X62071   Genomic Context:   Map View
UniSTS entries: SHGC-12640   Genomic Context:   Map View

EXPRESSION INFORMATION
cDNA sources: skin ;placenta ;uterus ;tonsil, enriched for germinal center b-cells ;foreskin, melanocyte ;lung ;brain ;eye ;small intestine ;sciatic nerve ;liver ;t cells from t cell leukemia ;cervix ;heart ;germ cell, pooled ;pool, lung+testis+b-cell ;adrenal gland ;lymph ;pool, placenta ;pool, melanocyte+heart+uterus ;whole embryo ;whole embryo, mainly head ;muscle ;testis ;placenta_normal ;bone ;pooled colon, kidney, stomach ;pancreas ;colon ;placenta human 8 week ;colon_ins ;leukocyte ;breast ;melanoma (mewo cell line) ;rpe and choroid ;mixed (pool of 40 rnas) ;salivary gland ;ovary ;stomach ;chondrosarcoma ;head_neck ;pool, liver+spleen ;kidney ;bladder
SAGE : Gene to Tag mapping

mRNA SEQUENCES (7)
NM_001798 Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant 1, mRNA P A 
M68520 Human cdc2-related protein kinase mRNA, complete cds P 
X61622 H.sapiens CDK2 mRNA P 
NM_052827 Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant 2, mRNA P A 
X62071 H.sapiens cdk2 mRNA P 
BC003065 Homo sapiens, cyclin-dependent kinase 2, clone MGC:1784 IMAGE:3504348, mRNA, complete cds P A 
AB012305 Homo sapiens mRNA for d-HSCDK2, complete cds P 

EST SEQUENCES (10 of 188)[Show all ESTs]
  BE386927 cDNA clone IMAGE:3615989 skin 5' read P M 
  BG825732 cDNA clone IMAGE:4899805 muscle 5' read P M 
  BQ217507 cDNA clone IMAGE:6050468 skin 5' read P M 
  BM463704 cDNA clone IMAGE:5518567 uterus 5' read P M 
  BQ226477 cDNA clone IMAGE:6055327 skin 5' read P M 
  BE277855 cDNA clone IMAGE:2966973 skin 5' read P M 
  BM924209 cDNA clone IMAGE:5760453 pooled colon, kidney, stomach 5' read P M 
  BM904985 cDNA clone IMAGE:5557819 skin 5' read P M 
  BQ220550 cDNA clone IMAGE:6055696 skin 5' read P M 
  BE384652 cDNA clone IMAGE:3617668 skin 5' read P M 

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
M Clone is putatively CDS-complete by MGC criteria


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