LOCUS LGMN 1981 bp mRNA linear PRI 05-NOV-2002 DEFINITION Homo sapiens legumain (LGMN), mRNA. ACCESSION NM_005606 VERSION NM_005606.3 GI:21914880 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1981) AUTHORS Tanaka,T., Inazawa,J. and Nakamura,Y. TITLE Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1 JOURNAL Cytogenet. Cell Genet. 74 (1-2), 120-123 (1996) MEDLINE 97049087 PUBMED 8893817 REFERENCE 2 (bases 1 to 1981) AUTHORS Chen,J.M., Dando,P.M., Rawlings,N.D., Brown,M.A., Young,N.E., Stevens,R.A., Hewitt,E., Watts,C. and Barrett,A.J. TITLE Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase JOURNAL J. Biol. Chem. 272 (12), 8090-8098 (1997) MEDLINE 97218252 PUBMED 9065484 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC003061.1. On Jul 22, 2002 this sequence version replaced gi:19923331. FEATURES Location/Qualifiers source 1..1981 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="14" /map="14q32.1" /clone="MGC:1395 IMAGE:3504506" /tissue_type="Placenta, choriocarcinoma" /clone_lib="NIH_MGC_21" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..1981 /gene="LGMN" /note="synonym: PRSC1" /db_xref="LocusID:5641" /db_xref="MIM:602620" CDS 142..1443 /gene="LGMN" /note="protease, cysteine, 1 (legumain)" /codon_start=1 /product="legumain" /protein_id="NP_005597.2" /db_xref="GI:21914881" /db_xref="LocusID:5641" /db_xref="MIM:602620" /translation="MVWKVAVFLSVALGIGAIPIDDPEDGGKHWVVIVAGSNGWYNYR HQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKD YTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNED LHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYA CYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTIS TMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEE IQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFN WHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY" misc_feature 157..1122 /gene="LGMN" /note="Peptidase_C13; Region: Peptidase C13 family. This family of peptidases is known as the hemoglobinase family because it contains a globin degrading enzyme from blood parasites. However relatives are found in plants and other organisms that have other functions. Members of this family are asparaginyl peptidases" /db_xref="CDD:pfam01650" variation 193 /gene="LGMN" /allele="G" /allele="A" /db_xref="dbSNP:2236264" variation 1272 /gene="LGMN" /allele="C" /allele="A" /db_xref="dbSNP:2281705" variation 1392 /gene="LGMN" /allele="G" /allele="A" /db_xref="dbSNP:9791" variation 1660 /gene="LGMN" /allele="A" /allele="-" /db_xref="dbSNP:3215728" variation 1730 /gene="LGMN" /allele="C" /allele="A" /db_xref="dbSNP:10465" BASE COUNT 527 a 505 c 493 g 456 t ORIGIN 1 ggcacgaggg aggctgcgag ccgccgcgag ttctcacggt cccgccggcg ccaccaccgc 61 ggtcactcac cgccgccgcc gccaccactg ccaccacggt cgcctgccac aggtgtctgc 121 aattgaactc caaggtgcag aatggtttgg aaagtagctg tattcctcag tgtggccctg 181 ggcattggtg ccattcctat agatgatcct gaagatggag gcaagcactg ggtggtgatc 241 gtggcaggtt caaatggctg gtataattat aggcaccagg cagacgcgtg ccatgcctac 301 cagatcattc accgcaatgg gattcctgac gaacagatcg ttgtgatgat gtacgatgac 361 attgcttact ctgaagacaa tcccactcca ggaattgtga tcaacaggcc caatggcaca 421 gatgtctatc agggagtccc gaaggactac actggagagg atgttacccc acaaaatttc 481 cttgctgtgt tgagaggcga tgcagaagca gtgaagggca taggatccgg caaagtcctg 541 aagagtggcc cccaggatca cgtgttcatt tacttcactg accatggatc tactggaata 601 ctggtttttc ccaatgaaga tcttcatgta aaggacctga atgagaccat ccattacatg 661 tacaaacaca aaatgtaccg aaagatggtg ttctacattg aagcctgtga gtctgggtcc 721 atgatgaacc acctgccgga taacatcaat gtttatgcaa ctactgctgc caaccccaga 781 gagtcgtcct acgcctgtta ctatgatgag aagaggtcca cgtacctggg ggactggtac 841 agcgtcaact ggatggaaga ctcggacgtg gaagatctga ctaaagagac cctgcacaag 901 cagtaccacc tggtaaaatc gcacaccaac accagccacg tcatgcagta tggaaacaaa 961 acaatctcca ccatgaaagt gatgcagttt cagggtatga aacgcaaagc cagttctccc 1021 gtccccctac ctccagtcac acaccttgac ctcaccccca gccctgatgt gcctctcacc 1081 atcatgaaaa ggaaactgat gaacaccaat gatctggagg agtccaggca gctcacggag 1141 gagatccagc ggcatctgga tgccaggcac ctcattgaga agtcagtgcg taagatcgtc 1201 tccttgctgg cagcgtccga ggctgaggtg gagcagctcc tgtccgagag agccccgctc 1261 acggggcaca gctgctaccc agaggccctg ctgcacttcc ggacccactg cttcaactgg 1321 cactccccca cgtacgagta tgcgttgaga catttgtacg tgctggtcaa cctttgtgag 1381 aagccgtatc cacttcacag gataaaattg tccatggacc acgtgtgcct tggtcactac 1441 tgaagagctg cctcctggaa gcttttccaa gtgtgagcgc cccaccgact gtgtgctgat 1501 cagagactgg agaggtggag tgagaagtct ccgctgctcg ggccctcctg gggagccccc 1561 gctccagggc tcgctccagg accttcttca caagatgact tgctcgctgt tacctgcttc 1621 cccagtcttt tctgaaaaac tacaaattag ggtgggaaaa gctctgtatt gagaagggtc 1681 atatttgctt tctaggaggt ttgttgtttt gcctgttagt tttgaggagc aggaagctca 1741 tgggggcttc tgtagcccct ctcaaaagga gtctttattc tgagaatttg aagctgaaac 1801 ctctttaaat cttcagaatg attttattga agagggccgc aagccccaaa tggaaaactg 1861 tttttagaaa atatgatgat ttttgattgc ttttgtattt aattctgcag gtgttcaagt 1921 cttaaaaaat aaagatttat aacagaaccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1981 a //