LOCUS       LGMN                     433 aa            linear   PRI 05-NOV-2002
DEFINITION  legumain; protease, cysteine, 1 (legumain) [Homo sapiens].
ACCESSION   NP_005597
VERSION     NP_005597.2  GI:21914881
DBSOURCE    REFSEQ: accession NM_005606.3
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Tanaka,T., Inazawa,J. and Nakamura,Y.
  TITLE     Molecular cloning of a human cDNA encoding putative cysteine
            protease (PRSC1) and its chromosome assignment to 14q32.1
  JOURNAL   Cytogenet. Cell Genet. 74 (1-2), 120-123 (1996)
  MEDLINE   97049087
   PUBMED   8893817
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Chen,J.M., Dando,P.M., Rawlings,N.D., Brown,M.A., Young,N.E.,
            Stevens,R.A., Hewitt,E., Watts,C. and Barrett,A.J.
  TITLE     Cloning, isolation, and characterization of mammalian legumain, an
            asparaginyl endopeptidase
  JOURNAL   J. Biol. Chem. 272 (12), 8090-8098 (1997)
  MEDLINE   97218252
   PUBMED   9065484
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC003061.1.
            On Jul 22, 2002 this sequence version replaced gi:5031991.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.1"
                     /clone="MGC:1395 IMAGE:3504506"
                     /tissue_type="Placenta, choriocarcinoma"
                     /clone_lib="NIH_MGC_21"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     Protein         1..433
                     /product="legumain"
                     /note="protease, cysteine, 1 (legumain)"
     Region          6..327
                     /region_name="Peptidase C13 family. This family of
                     peptidases is known as the hemoglobinase family because it
                     contains a globin degrading enzyme from blood parasites.
                     However relatives are found in plants and other organisms
                     that have other functions. Members of this family are
                     asparaginyl peptidases"
                     /note="Peptidase_C13"
                     /db_xref="CDD:pfam01650"
     variation       18
                     /allele="V"
                     /allele="I"
                     /db_xref="dbSNP:2236264"
     variation       377
                     /allele="S"
                     /allele="R"
                     /db_xref="dbSNP:2281705"
     CDS             1..433
                     /gene="LGMN"
                     /coded_by="NM_005606.3:142..1443"
                     /db_xref="LocusID:5641"
                     /db_xref="MIM:602620"
ORIGIN      
        1 mvwkvavfls valgigaipi ddpedggkhw vvivagsngw ynyrhqadac hayqiihrng
       61 ipdeqivvmm yddiaysedn ptpgivinrp ngtdvyqgvp kdytgedvtp qnflavlrgd
      121 aeavkgigsg kvlksgpqdh vfiyftdhgs tgilvfpned lhvkdlneti hymykhkmyr
      181 kmvfyieace sgsmmnhlpd ninvyattaa npressyacy ydekrstylg dwysvnwmed
      241 sdvedltket lhkqyhlvks htntshvmqy gnktistmkv mqfqgmkrka sspvplppvt
      301 hldltpspdv pltimkrklm ntndleesrq lteeiqrhld arhlieksvr kivsllaase
      361 aeveqllser apltghscyp eallhfrthc fnwhsptyey alrhlyvlvn lcekpyplhr
      421 iklsmdhvcl ghy
//