Pairwise Comparsion
Nucleotide sequence alignments
Residues with shared chemical properties can substitute for each other
Size, charge, hydrophobicity, polarity
scored less than a match, but better than a mismatch
Conservative changes scored as better than non-conservative
 137 AGACCAACCTGGCCAACATGGTGAAATCCCATCTCTAC.AAAAATACAAA 185
     |||||| |||||||||||||||||||  ||||||||||  ||||||||||
   1 AGACCAGCCTGGCCAACATGGTGAAACTCCATCTCTACTGAAAATACAAA 50
match
mismatch
gap
Protein sequence alignments
Conserved substitution
                     10        20        30        40        50        60
ggamma.pep   MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
             |||||||||||||||||:|||::|||||:|||||:|||||||||||||||||||||||||
HGCZG        MGHFTEEDKATITSLWGHVNVDEAGGETIGRLLVLYPWTQRFFDSFGNLSSASAIMGNPK
                     10        20        30        40        50        60