Domains and
Sites of the
commonly used signature databases, and has an intuitive interface for text- and
sequence-based searches.
Bioinformatics
infrastructural activities are crucial to modern biological research. Complete
and up-to-date databases of biological knowledge are vital for the
increasingly information-dependent biological and
biotechnological research. Secondary protein databases on functional sites and
domains
like PROSITE, PRINTS, SMART, Pfam, ProDom, etc. are vital resources for
identifying distant relationships in novel sequences, and
hence for predicting protein function and structure. Unfortunately,
these signature databases do not share the same formats and nomenclature, and each database has
is own strengths and weaknesses.
To capitalise on these, the following partners: EBI, SIB, University of Manchester, Sanger Institute, GENE-IT, CNRS/INRA, LION bioscience AG and University of Bergen unified PROSITE, PRINTS, ProDom and Pfam into InterPro (Integrated resource of Protein Families, Domains and Sites). The latest databases to join the project were SMART, and more recently, TIGRFAMs.
To capitalise on these, the following partners: EBI, SIB, University of Manchester, Sanger Institute, GENE-IT, CNRS/INRA, LION bioscience AG and University of Bergen unified PROSITE, PRINTS, ProDom and Pfam into InterPro (Integrated resource of Protein Families, Domains and Sites). The latest databases to join the project were SMART, and more recently, TIGRFAMs.
http://www.ebi.ac.uk/Tools/pfa/iprscan/