What’s the difference?
(3) Logic
•Hypothesis-driven research to data-driven research
•Expertise-driven approach versus information-driven approach
•Reductionist versus integrationist
•How to answer the question becomes how to question an answer
•Algorithmic approaches for filtering, normalizing, analyzing and interpreting become increasingly important
It’s hard to be an expert on 25,000+ genes
In molecular biology cleverness is finding a way to answer a question definitively by ignoring 99.99% of genes.  You can’t see them, so the experiment must exclude them.