A DNA microarray (also commonly known
as gene or genome chip, DNA chip, or gene array) is a collection of
microscopic DNA spots, commonly representing single genes, arrayed on a solid
surface by covalent attachment to a chemical matrix. DNA arrays are different
from other types of microarray only in that they either measure DNA or use DNA as part of its detection system. Qualitative or quantitative measurements with DNA microarrays utilize
the selective nature of DNA-DNA or DNA-RNA hybridization under high-stringency
conditions and fluorophore-based detection. DNA arrays are commonly used for
expression profiling, i.e., monitoring expression levels of thousands of genes
simultaneously, or for comparative genomic hybridization.