ØA need to establish a
public repository or repositories for microarray gene expression data became
apparent in 1998, which requires data standards
ØMGED-1 (Microarray Gene Expression Database) Group:
November 14-15, 1999, Cambridge, UK
–Established five working groups, including the microarray data annotation group (MIAME)
ØMGED-2: May 25 - 27, 2000, Heidelberg, Germany
–Endorsed a MIAME draft
ØMGED-3: March 29-31, 2001, Stanford University
–Adopted MIAME 1.0
ØMGED-4: Feb. 13-16, 2002, Boston
–Adopted MIAME 1.1
MIAME (Minimum
Information
About a Microarray
Experiment)
Images
Spot/Image quantization
Samples
Gene expression levels
Gene Expression Matrix
The final gene expression matrix (on the right) is needed for higher level analysis and mining.
MIAME is a standard for reporting microarray experiments. It is intended to
specify all the information necessary to interpret the results of the
experiment unambiguously and to potentially to reproduce the experiment. While
the standard defines the content required for compliant reports, it does not
specify the format in which this data should be presented. There are a number
of file formats for representing this data, and both public and
subscription-based repositories for such experiments. (