SeqWeb Version 2 supports the following platforms with the following web browsers:
| Task | Netscape | Internet Explorer |
| Loading pages |   | Loads pages faster. |
| Printing pages | Sometimes runs out of memory. | Prints faster and more reliably. |
| Refreshing window contents | Must sometimes "Reload" the page to see the effect of a previous action, such as adding a sequence. Reloading may return you to the main SeqWeb page rather than the page in which you were working. | Must sometimes "Reload" the page to see the effect of a previous action, such as adding a sequence. |
| Resizing the browser window | Must sometimes "Reload" the page after resizing (due to a JavaScript bug). Reloading may return you to the main SeqWeb page rather than the page in which you were working. | Resizes pages more gracefully. |
| Saving files | Supports saving multiple files at one time. | Saves only one file at a time. |
| Status line display | Provides a larger status line, good for displaying more of the sequence or results description. |   |